Toxic Effects of Carbon Nanoparticles on Mice Cells

By using rats as materials, the baby rats were given intraperitoneal injections of nanocarbon solutions with the concentration of 0%, 20%, 40% and80% for3d, 5d, 8d respectively, to test the effects of the nanocarbon on the superoxide dismutase(SOD) activity and apoptosis of mice bone marrow cells in rats’ liver cells. The result shows: the nanocarbon stress on the activity of SOD in liver tissue of rats has significant time-dose effect and concentrations effect; the effect of nanocarbon on SOD activity displays a general trend of inhibition- induction- inhibition; on the dose effect, Low and Medium concentra- tions of nanocarbon displays an inhibition state firstly, while high concentrations of nanocarbon has certain induction effect yet after a certain period of time, the effect of low concentration of nanocarbon on SOD activity will still be inhibited; at high or medium concentrations it appears to be an induced phenomenon; under sustained stress, for each concentration group it shows a phenomenon of toxicant inhibition; the activity of SOD is significantly decreased. Under the stresses of different concentra- tions of nanocarbon, the apoptosis of rat bone marrow cells induced by nanocarbon has a concentration effect and time effect; compared with the control group, the difference is significant(P< 0. 05), indicating that rats can be used as an indicator of nano-materials to test the toxicity of higher animals. Conclusion: Carbon nanoparticles have a fairly strong physiological and inherent toxicity on rats.